Cholesterol catabolism in patients with acute myelogenous leukemia and hypocholesterolemia: suppressed levels of a circulating marker for bile acid synthesis
Identifieur interne : 000C30 ( Main/Exploration ); précédent : 000C29; suivant : 000C31Cholesterol catabolism in patients with acute myelogenous leukemia and hypocholesterolemia: suppressed levels of a circulating marker for bile acid synthesis
Auteurs : Loukas Tatidis [Suède] ; Sigurd Vitols [Suède] ; Astrid Gruber [Suède] ; Christer Paul [Suède] ; Magnus Axelson [Suède]Source :
- Cancer Letters [ 0304-3835 ] ; 2001.
Descripteurs français
- KwdFr :
- Acides et sels biliaires (biosynthèse), Adulte d'âge moyen (MeSH), Cholesténones (sang), Cholestérol (métabolisme), Cholestérol (sang), Déhydrocholestérols (sang), Femelle (MeSH), Humains (MeSH), Leucémie aigüe myéloïde (sang), Lipoprotéines LDL (métabolisme), Marqueurs biologiques (analyse), Mâle (MeSH), Radio-isotopes de l'iode (MeSH), Sujet âgé (MeSH).
- MESH :
- analyse : Marqueurs biologiques.
- biosynthèse : Acides et sels biliaires.
- métabolisme : Cholestérol, Lipoprotéines LDL.
- sang : Cholesténones, Cholestérol, Déhydrocholestérols, Leucémie aigüe myéloïde.
- Adulte d'âge moyen, Femelle, Humains, Mâle, Radio-isotopes de l'iode, Sujet âgé.
English descriptors
- KwdEn :
- Acute myelogenous leukemia, Aged (MeSH), Bile Acids and Salts (biosynthesis), Bile acids, Biomarkers (analysis), Cholestenones (blood), Cholesterol, Cholesterol (blood), Cholesterol (metabolism), Dehydrocholesterols (blood), Female (MeSH), Humans (MeSH), Iodine Radioisotopes (MeSH), Leukemia, Myeloid, Acute (blood), Lipoproteins, LDL (metabolism), Low-density lipoprotein, Male (MeSH), Middle Aged (MeSH).
- MESH :
- chemical , analysis : Biomarkers.
- chemical , biosynthesis : Bile Acids and Salts.
- chemical , blood : Cholestenones, Cholesterol, Dehydrocholesterols.
- chemical , metabolism : Cholesterol, Lipoproteins, LDL.
- blood : Leukemia, Myeloid, Acute.
- Aged, Female, Humans, Iodine Radioisotopes, Male, Middle Aged.
Abstract
Hypocholesterolemia is a frequent finding in patients with acute myelogenous leukemia (AML) and in other types of malignancies. Since bile acids are major excretion products of cholesterol, the hepatic degradation of cholesterol to bile acids was investigated in AML patients by analyzing a circulating marker for bile acid synthesis. In addition, plasma levels of a marker for cholesterol synthesis were determined. The plasma levels of 7α-hydroxy-4-cholesten-3-one, reflecting bile acid production, were markedly lower in patients with AML than in healthy controls. The median levels were 3.3 and 18.5ng/ml (P<0.0001) in the AML patients (n=29) and the healthy subjects (n=16), respectively. The plasma levels of 7-dehydrocholesterol, reflecting hepatic cholesterol synthesis, were similar for the AML patients and the controls. The results show that the conversion of cholesterol to bile acids was suppressed in AML patients, a phenomenon that may result in a decreased intestinal absorption of cholesterol and subsequent hypocholesterolemia.
Url:
DOI: 10.1016/S0304-3835(01)00592-4
Affiliations:
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Le document en format XML
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Department of Medicine, Karolinska Institute and Hospital, Stockholm, S-171 76</wicri:regionArea><wicri:noRegion>S-171 76</wicri:noRegion></affiliation></author><author><name sortKey="Paul, Christer" sort="Paul, Christer" uniqKey="Paul C" first="Christer" last="Paul">Christer Paul</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Hematology, Huddinge University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Axelson, Magnus" sort="Axelson, Magnus" uniqKey="Axelson M" first="Magnus" last="Axelson">Magnus Axelson</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Chemistry, Karolinska Institute and Hospital, Stockholm, S-171 76</wicri:regionArea><wicri:noRegion>S-171 76</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Cancer Letters</title><title level="j" type="abbrev">CAN</title><idno type="ISSN">0304-3835</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">170</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="169">169</biblScope><biblScope unit="page" to="175">175</biblScope></imprint><idno type="ISSN">0304-3835</idno></series><idno type="istex">E84BDF6040593E3097CF97D2AB0955C14E4F790E</idno><idno type="DOI">10.1016/S0304-3835(01)00592-4</idno><idno type="PII">S0304-3835(01)00592-4</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-3835</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute myelogenous leukemia</term><term>Aged (MeSH)</term><term>Bile Acids and Salts (biosynthesis)</term><term>Bile acids</term><term>Biomarkers (analysis)</term><term>Cholestenones (blood)</term><term>Cholesterol</term><term>Cholesterol (blood)</term><term>Cholesterol (metabolism)</term><term>Dehydrocholesterols (blood)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Iodine Radioisotopes (MeSH)</term><term>Leukemia, Myeloid, Acute (blood)</term><term>Lipoproteins, LDL (metabolism)</term><term>Low-density lipoprotein</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acides et sels biliaires (biosynthèse)</term><term>Adulte d'âge moyen (MeSH)</term><term>Cholesténones (sang)</term><term>Cholestérol (métabolisme)</term><term>Cholestérol (sang)</term><term>Déhydrocholestérols (sang)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Leucémie aigüe myéloïde (sang)</term><term>Lipoprotéines LDL (métabolisme)</term><term>Marqueurs biologiques (analyse)</term><term>Mâle (MeSH)</term><term>Radio-isotopes de l'iode (MeSH)</term><term>Sujet âgé (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Bile Acids and Salts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cholestenones</term><term>Cholesterol</term><term>Dehydrocholesterols</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cholesterol</term><term>Lipoproteins, LDL</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Marqueurs biologiques</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Acides et sels biliaires</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Leukemia, Myeloid, Acute</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cholestérol</term><term>Lipoprotéines LDL</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Cholesténones</term><term>Cholestérol</term><term>Déhydrocholestérols</term><term>Leucémie aigüe myéloïde</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Iodine Radioisotopes</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Radio-isotopes de l'iode</term><term>Sujet âgé</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hypocholesterolemia is a frequent finding in patients with acute myelogenous leukemia (AML) and in other types of malignancies. Since bile acids are major excretion products of cholesterol, the hepatic degradation of cholesterol to bile acids was investigated in AML patients by analyzing a circulating marker for bile acid synthesis. In addition, plasma levels of a marker for cholesterol synthesis were determined. The plasma levels of 7α-hydroxy-4-cholesten-3-one, reflecting bile acid production, were markedly lower in patients with AML than in healthy controls. The median levels were 3.3 and 18.5ng/ml (P<0.0001) in the AML patients (n=29) and the healthy subjects (n=16), respectively. The plasma levels of 7-dehydrocholesterol, reflecting hepatic cholesterol synthesis, were similar for the AML patients and the controls. The results show that the conversion of cholesterol to bile acids was suppressed in AML patients, a phenomenon that may result in a decreased intestinal absorption of cholesterol and subsequent hypocholesterolemia.</div></front></TEI><affiliations><list><country><li>Suède</li></country><region><li>Svealand</li></region><settlement><li>Stockholm</li></settlement></list><tree><country name="Suède"><noRegion><name sortKey="Tatidis, Loukas" sort="Tatidis, Loukas" uniqKey="Tatidis L" first="Loukas" last="Tatidis">Loukas Tatidis</name></noRegion><name sortKey="Axelson, Magnus" sort="Axelson, Magnus" uniqKey="Axelson M" first="Magnus" last="Axelson">Magnus Axelson</name><name sortKey="Gruber, Astrid" sort="Gruber, Astrid" uniqKey="Gruber A" first="Astrid" last="Gruber">Astrid Gruber</name><name sortKey="Paul, Christer" sort="Paul, Christer" uniqKey="Paul C" first="Christer" last="Paul">Christer Paul</name><name sortKey="Tatidis, Loukas" sort="Tatidis, Loukas" uniqKey="Tatidis L" first="Loukas" last="Tatidis">Loukas Tatidis</name><name sortKey="Vitols, Sigurd" sort="Vitols, Sigurd" uniqKey="Vitols S" first="Sigurd" last="Vitols">Sigurd Vitols</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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